Otomite Plus is a topical liquid solution designed for application directly into the ear canal of dogs and cats. The formula combines pyrethrins with two synergist ingredients, piperonyl butoxide and n-octyl bicycloheptene dicarboximide, carried in an olive oil vehicle intended to disperse through the ear canal without leaving a greasy feel. Each package contains a single bottle of the liquid, and no assembly or mixing is required before use. The ear should be cleansed with an appropriate ear cleanser prior to each application, and the bottle should be shaken before dispensing. Treatment is typically repeated on a weekly schedule depending on the severity of the condition, and all household pets are commonly treated together to help reduce the chance of mites spreading between animals. The product is intended for dogs and cats that are at least 12 weeks of age.