Effipro Plus Topical Solution for Dogs is a liquid spot-on treatment packaged as single-use applicators for large dogs and puppies 8 weeks of age or older weighing 45 to 88.9 pounds. Each applicator combines fipronil, which acts against fleas, ticks, and chewing lice, with pyriproxyfen, an insect growth regulator that targets flea eggs and larvae. The solution also aids in the control of sarcoptic mite infestations. To apply, the fur between the shoulder blades is parted until skin is visible, and the full contents of the applicator are deposited directly onto the skin in the recommended number of spots for the dog's size. The formulation remains effective after bathing, shampooing, water immersion, or sun exposure. Each carton contains three applicators, supporting three consecutive months of treatment. Hands should be washed after handling, and treated dogs should be kept away from cats for 24 hours following application.